Nobiletin Enhances the Chemotherapeutic Efficacy of Docetaxel through Inhibition of Phosphatidylinositol 3-Kinase/Protein Kinase B and Induction of Apoptosis in Colon Cancer Cells

Nobiletin is considered a phyto-flavonoid extracted from citrus peel and shown to several pharmacological roles such as anti-inflammatory, anti-tumor neuroprotective properties. In this study, we investigate the role of nobiletin combined docetaxel enhances apoptosis in colorectal cancer cell lines. Our results confirmed enhanced docetaxel-induced reactive oxygen species generation human carcinoma cells also mitochondrial membrane potential damage cells. We have been noticed that improved mediated death by dual acridine orange/ethidium bromide assay. Phosphatidylinositol 3-kinase/protein kinase B phosphorylation heavily involved survival proliferation. inhibits phosphatidylinositol B's when with treated Moreover, augmented expression levels pro-apoptotic genes Bax, cytochrome c, caspase 9 3 proteins foremost down regulation anti-apoptotic gene protein B-cell lymphoma 2. Hence, possibly augmenting colon compassion chemotherapy offer cellular origin for nobiletin’s latent tenders chemo sensitization